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第40章 锋芒

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“Good afternoon, everyone. My name is Su Wan, from Nanjiang Medical University, China.”

苏晚的声音透过麦克风,清晰,平稳,带着一丝不易察觉的紧张,但更多的是坚定。会场里很安静,一百多双眼睛看着她,有审视,有好奇,也有鼓励。

她按下翻页笔,第一张幻灯片亮起。简洁的标题,清晰的署名,干净的结构图。

“Today, I will present our findings on the genetic risk factors for drug-induced liver injury, based on a clinical and bioinformatic analysis of over two thousand patients.”

她开始讲述背景。药物性肝损伤的发病率,现有研究的局限性,她们为什么要做这个分析。语速不疾不徐,关键词用重音强调,复杂的术语用简单的语言解释。眼睛看着观众,偶尔看向幻灯片,但从不长时间停留。

第二张,第三张,第四张……幻灯片一页页翻过。数据清洗的方法,样本的描述性统计,亚组的划分标准。她讲得很清楚,逻辑线很清晰。台下有人开始点头,有人低头做笔记。

到了最关键的部分——分析结果。她放慢了语速。

“In the subgroup of patients carrying a specific HLA genotype, we observed a significantly higher risk of drug-induced liver injury. The hazard ratio, after adjusting for all confounding factors, was 3.5.”

她点开森林图。屏幕上,那个亚组的风险比置信区间,远远偏离了1。很醒目,很刺眼。

会场里响起一阵低低的议论声。有人交头接耳,有人往前探了探身,想看得更清楚。苏晚的心脏跳得很快,但她强迫自己稳住,继续。

“We validated this finding in two independent datasets, and the results were consistent. Moreover, in the expanded validation cohort, the hazard ratio increased to 4.2.”

她又点开两张验证结果的幻灯片。数据,图表,统计值。每一个数字,都扎扎实实,无可辩驳。

“Based on these findings, we propose that this specific HLA genotype may serve as a genetic biomarker for identifying high-risk individuals before drug administration. This could potentially guide personalized treatment strategies and improve drug safety.”

她说完,按下最后一页幻灯片。是致谢,感谢李主任,徐敏,北科院,还有……她的目光飘向会场后方,那个靠墙站着的身影。江屹。

“Thank you.”她微微鞠躬。

掌声响起。起初是礼貌性的,然后越来越热烈,持续了十几秒。苏晚站在台上,看着台下鼓掌的人群,心脏还在狂跳,但脸上露出了笑容。很淡,但很真实。

主持人上台,笑着说了几句赞扬的话,然后进入提问环节。

“Any questions for Ms. Su?”他看向台下。

一只手举了起来。是个五十多岁的白人男性,戴着眼镜,表情严肃。

“Yes, Dr. Johnson, please.”

Johnson教授站起来,接过工作人员递来的麦克风。

“Thank you for the excellent presentation, Ms. Su. I have two questions. First, regarding the sample size of your validation cohort. You mentioned it was expanded, but how many patients were actually included? And second, have you done any functional studies to explore the biological mechanism behind this association?”

很犀利的问题。苏晚深吸一口气,拿起麦克风。

“Thank you for your questions, Dr. Johnson. For the first question, the expanded validation cohort included an additional five hundred patients from three different medical centers. The total sample size for validation is now over seven hundred, and the association remains significant.”

她顿了顿,继续说:“For the second question, we are currently collaborating with a molecular biology lab to investigate the functional mechanism. Preliminary data suggest that this specific HLA genotype may affect antigen presentation, leading to an altered immune response. But this is still ongoing work, and we hope to have more concrete results in the near future.”

Johnson教授点了点头,没再追问,坐下了。

又有人举手。是个年轻的女学者,问的是统计方法的选择,为什么用Cox模型而不是其他。苏晚一一回答,引经据典,数据详实,逻辑清晰。她越说越稳,越说越自信,眼睛里闪着光。

江屹站在后方,靠着墙,看着她。台上的女孩,穿着得体的西装,头发盘得一丝不苟,站在世界顶级的学术舞台上,面对最挑剔的同行,从容不迫,对答如流。灯光打在她身上,像给她镀了一层金边。

他忽然想起第一次见她时的样子。雨夜,巷子,她哆哆嗦嗦地举着手机,眼睛却亮得像星星。那么小,那么脆弱,却又那么……勇敢。

而现在,她站在这里,站在世界的中央,发出自己的光。

心里是满的,是骄傲的,也是……酸楚的。骄傲她的成长,酸楚她的辛苦。这三个月,她是怎么熬过来的,他比谁都清楚。那些不眠不休的夜晚,那些一遍又一遍的演练,那些自我怀疑和崩溃的瞬间……她都一个人扛过来了。

而现在,她做到了。

提问环节持续了十分钟。苏晚回答了所有问题,没有一个被问倒。最后,主持人笑着总结:“Excellent work, Ms. Su. Thank you for sharing this important finding with us.”

“苏女士,你的研究非常出色,感谢您与我们分享这一重要发现。”

掌声再次响起。这一次,更热烈,更真诚。苏晚鞠躬,下台。走到座位时,旁边几个年轻学者朝她竖起大拇指。她笑了笑,坐下,手心里全是汗,但心里是前所未有的轻松和……喜悦。

她做到了。真的做到了。

会议继续进行,下一个讲者上台。苏晚坐在座位上,听着,但心思已经飘远了。她想起江屹,想起他说的“享受站在台上的那十五分钟”。她确实享受了。那种分享知识的快乐,那种被认可的满足,那种……证明自己的骄傲。

中场休息时,很多人围过来。有祝贺的,有交换名片的,有约着下次合作的。苏晚一一应对,礼貌,得体。英语虽然还有口音,但交流无碍。

“Su, your presentation was brilliant.”一个三十来岁的女学者走过来,递给她一张名片,“I'm Sarah, from Harvard. We're doing similar work on pharmacogenomics. I'd love to collaborate with you, if you're interested.”

哈佛。苏晚心里一跳,接过名片,认真地说:“Thank you, Dr. Sarah. I'm very interested. My email is on the abstract book. Please feel free to contact me.”

“谢谢萨拉博士,我对此非常感兴趣。我的邮箱在摘要集里,您随时可以联系我。”

“Great.”Sarah笑了,“I'll email you next week. Keep up the good work.”

“我下周会给你发邮件,继续加油。”

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